In vivo spatiotemporal dynamics of astrocyte reactivity following neural electrode implantation.

ABSTRACT: Brain computer interfaces (BCIs), including penetrating microelectrode arrays, enable both recording and stimulation of neural cells. However, device implantation inevitably causes injury to brain tissue and induces a foreign body response, leading to reduced recording performance and stimulation efficacy. Astrocytes in the healthy brain play multiple roles including regulating energy metabolism, homeostatic balance, transmission of neural signals, and neurovascular coupling. Following an insult to the brain, they are activated and gather around the site of injury. These reactive astrocytes have been regarded as one of the main contributors to the formation of a glial scar which affects the performance of microelectrode arrays. This study investigates the dynamics of astrocytes within the

SUBMITTER: Savya SP 

PROVIDER: S-EPMC10231871 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature