Clinicopathological and immunological features of new onset kidney disease: a rare event after SARS-CoV-2 vaccination.

ABSTRACT: The onset of various kidney diseases has been reported after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. However, detailed clinical and pathological features are lacking. We screened and analyzed patients with newly diagnosed kidney diseases after inactivated SARS-CoV-2 vaccination in Peking University First Hospital from January 2021 to August 2021, and compared them with the reported cases in the literature. We obtained samples of blood, urine and renal biopsy tissues. Clinical and laboratory information, as well as light microscopy, immunostaining and ultrastructural observations, were described. The SARS-CoV-2 spike protein and nucleoprotein were stained using the immunofluorescence technique in the kidney biopsy samples. SARS-CoV-2 specific antibodies wer

SUBMITTER: Zhang YM 

PROVIDER: S-EPMC10232013 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature