Dual orexin receptor antagonists for the treatment of insomnia: systematic review and network meta-analysis.

ABSTRACT:

Background

 Several randomized clinical trials (RCTs) have shown that dual orexin receptor antagonists (DORAs) are effective in the treatment of chronic insomnia. However, the superiority of one particular DORA over the others remains unclear.

Objective

 To perform a network meta-analysis to evaluate the efficacy of different DORAs in patients with chronic insomnia.

Methods

 The Medline, Embase, and Cochrane Central databases were searched for RCTs that compared DORA with placebo in patients ≥ 18 years of age with a diagnosis of insomnia disorder. We pooled outcomes for wake time after sleep onset (WASO), latency to persistent sleep (LPS), total sleep time (TST), and adverse events (AEs).

Results

 We included 10 RCTs with 7,806 patients, 4,849 of whom received

SUBMITTER: Rocha RB 

PROVIDER: S-EPMC10232020 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature