A novel breakthrough in wrist-worn transdermal troponin-I-sensor assessment for acute myocardial infarction.

ABSTRACT:

Aims

Clinical differentiation of acute myocardial infarction (MI) from unstable angina and other presentations mimicking acute coronary syndromes (ACS) is critical for implementing time-sensitive interventions and optimizing outcomes. However, the diagnostic steps are dependent on blood draws and laboratory turnaround times. We tested the clinical feasibility of a wrist-worn transdermal infrared spectrophotometric sensor (transdermal-ISS) in clinical practice and assessed the performance of a machine learning algorithm for identifying elevated high-sensitivity cardiac troponin-I (hs-cTnI) levels in patients hospitalized with ACS.

Methods and results

We enrolled 238 patients hospitalized with ACS at five sites. The final diagnosis of MI (with or without ST elevation) and unst

SUBMITTER: Sengupta S 

PROVIDER: S-EPMC10232240 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature