Thalamostriatal disconnection underpins long-term seizure freedom in frontal lobe epilepsy surgery.

ABSTRACT: Around 50% of patients undergoing frontal lobe surgery for focal drug-resistant epilepsy become seizure free post-operatively; however, only about 30% of patients remain seizure free in the long-term. Early seizure recurrence is likely to be caused by partial resection of the epileptogenic lesion, whilst delayed seizure recurrence can occur even if the epileptogenic lesion has been completely excised. This suggests a coexistent epileptogenic network facilitating ictogenesis in close or distant dormant epileptic foci. As thalamic and striatal dysregulation can support epileptogenesis and disconnection of cortico-thalamostriatal pathways through hemispherotomy or neuromodulation can improve seizure outcome regardless of focality, we hypothesize that projections from the striatum and the thal

SUBMITTER: Giampiccolo D 

PROVIDER: S-EPMC10232243 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature