Reproductive characteristics, use of exogenous hormones and Parkinson disease in women from the E3N study.

ABSTRACT: Despite experimental studies suggesting a disease-modifying role of oestrogens, results from epidemiological studies on the relation of reproductive characteristics and hormonal exposures with Parkinson disease in women are conflicting. We used the data from the E3N cohort study including 98 068 women aged 40-65 years in 1990 followed until 2018. Parkinson disease was ascertained using a validation process based on drug claim databases and medical records. Reproductive characteristics and hormonal exposures were self-reported (11 questionnaires). Associations of exposures with Parkinson disease incidence were investigated using time-varying Cox proportional hazards regression with a 5-year exposure lag and age as the timescale adjusted for confounders. We identified 1165 incident Parkinson

SUBMITTER: Pesce G 

PROVIDER: S-EPMC10232244 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature