A novel eye-movement impairment in multiple sclerosis indicating widespread cortical damage.

ABSTRACT: In multiple sclerosis, remyelination trials have yet to deliver success like that achieved for relapse rates with disease course modifying treatment trials. The challenge is to have a clinical, functional outcome measure. Currently, there are none that have been validated, other than visual evoked potentials in optic neuritis. Like vision, quick eye movements (saccades) are heavily dependent on myelination. We proposed that it is possible to extrapolate from demyelination of the medial longitudinal fasciculus in the brainstem to quantitative assessment of cortical networks governing saccadic eye movements in multiple sclerosis. We have developed and validated a double-step saccadic test, which consists of a pair of eye movements towards two stimuli presented in quick succession (the demons

SUBMITTER: Nij Bijvank JA 

PROVIDER: S-EPMC10232247 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature