Reward insensitivity is associated with dopaminergic deficit in rapid eye movement sleep behaviour disorder.

ABSTRACT: Idiopathic rapid eye movement sleep behaviour disorder (iRBD) has now been established as an important marker of the prodromal stage of Parkinson's disease and related synucleinopathies. However, although dopamine transporter single photon emission computed tomography (SPECT) has been used to demonstrate the presence of nigro-striatal deficit in iRBD, quantifiable correlates of this are currently lacking. Sensitivity to rewarding stimuli is reduced in some people with Parkinson's disease, potentially contributing to aspects of the neuropsychiatric phenotype in these individuals. Furthermore, a role for dopaminergic degeneration is suggested by the fact that reward insensitivity can be improved by dopaminergic medications. Patients with iRBD present a unique opportunity to study the relatio

SUBMITTER: Barber TR 

PROVIDER: S-EPMC10232265 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature