Dynamic mitochondrial transcription and translation in B cells control germinal center entry and lymphomagenesis.

ABSTRACT: Germinal center (GC) B cells undergo proliferation at very high rates in a hypoxic microenvironment but the cellular processes driving this are incompletely understood. Here we show that the mitochondria of GC B cells are highly dynamic, with significantly upregulated transcription and translation rates associated with the activity of transcription factor A, mitochondrial (TFAM). TFAM, while also necessary for normal B cell development, is required for entry of activated GC precursor B cells into the germinal center reaction; deletion of Tfam significantly impairs GC formation, function and output. Loss of TFAM in B cells compromises the actin cytoskeleton and impairs cellular motility of GC B cells in response to chemokine signaling, leading to their spatial disorganization. We show that

SUBMITTER: Yazicioglu YF 

PROVIDER: S-EPMC10232359 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature