Gap junctions desynchronize a neural circuit to stabilize insect flight.

ABSTRACT: Insect asynchronous flight is one of the most prevalent forms of animal locomotion used by more than 600,000 species. Despite profound insights into the motor patterns¹, biomechanics^2,3 and aerodynamics underlying asynchronous flight^4,5, the architecture and function of the central-pattern-generating (CPG) neural network remain unclear. Here, on the basis of an experiment-theory approach including electrophysiology, optophysiology, Drosophila genetics and mathematical modelling, we identify a miniaturized circuit solution with unexpected properties. The CPG network consists of motoneurons interconnected by electrical synapses that, in contrast to doctrine, produce network activity splayed out in time instead of synchronized across neurons. Experimental and

SUBMITTER: Hurkey S 

PROVIDER: S-EPMC10232364 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature