Polyketides with potential bioactivities from the mangrove-derived fungus Talaromyces sp. WHUF0362.

ABSTRACT: Metabolites of microorganisms have long been considered as potential sources for drug discovery. In this study, five new depsidone derivatives, talaronins A-E (1-5) and three new xanthone derivatives, talaronins F-H (6-8), together with 16 known compounds (9-24), were isolated from the ethyl acetate extract of the mangrove-derived fungus Talaromyces species WHUF0362. The structures were elucidated by analysis of spectroscopic data and chemical methods including alkaline hydrolysis and Mosher's method. Compounds 1 and 2 each attached a dimethyl acetal group at the aromatic ring. A putative biogenetic relationship of the isolated metabolites was presented and suggested that the depsidones and the xanthones probably had the same biosynthetic precursor

SUBMITTER: Lv H 

PROVIDER: S-EPMC10232383 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature