GPX4 overexpressed non-small cell lung cancer cells are sensitive to RSL3-induced ferroptosis.

ABSTRACT: Ferroptosis can be induced by inhibiting antioxidant enzymes GPX4 or system Xc^-, increased intracellular iron concentrations, and lipid peroxidation. Recently, it has been suggested that ferroptosis can be an effective way to induce cancer cell death, although the specific relevance and mechanism of ferroptosis have not been fully elucidated. Here, we investigated the anticancer effects of ferroptosis inducers erastin and RSL3 on non-small cell lung cancer (NSCLC) cells. RSL3 induced cell death more effectively in NSCLC cells than erastin, with limited cytotoxicity in BEAS-2B normal bronchial epithelial cells. The sensitivity of NSCLC cells to RSL3 induced death was dependent on GPX4 expression levels; the effect of RSL3 was reversed by ferrostatin-1 (a ferroptosis inhibitor) bu

SUBMITTER: Kim JW 

PROVIDER: S-EPMC10232506 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature