The impact of TLR2 and aging on the humoral immune response to Staphylococcus aureus bacteremia in mice.

ABSTRACT: Aging alters immunoglobulin production, affecting the humoral immune response. Toll-like receptor 2 (TLR2) recognizes Staphylococcus aureus (S. aureus) which causes bacteremia with high mortality in the elderly. To understand how TLR2 and aging affect the humoral immune response in bacteremia, four groups of mice (wild type-young, wild type-old, TLR2^-/--young, and TLR2^-/--old) were used to analyze immunoglobulin levels in healthy conditions as well as 10 days after intravenous injection with S. aureus. We found that aging increased the levels of both IgM and IgG. Increased IgG in aged mice was controlled by TLR2. In bacteremia infection, aged mice failed to mount proper IgM response in both wild-type (WT) and TLR2^-/- mice, whereas IgG response was impaired

SUBMITTER: Gupta P 

PROVIDER: S-EPMC10232519 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature