Host-diet-gut microbiome interactions influence human energy balance: a randomized clinical trial.

ABSTRACT: The gut microbiome is emerging as a key modulator of human energy balance. Prior studies in humans lacked the environmental and dietary controls and precision required to quantitatively evaluate the contributions of the gut microbiome. Using a Microbiome Enhancer Diet (MBD) designed to deliver more dietary substrates to the colon and therefore modulate the gut microbiome, we quantified microbial and host contributions to human energy balance in a controlled feeding study with a randomized crossover design in young, healthy, weight stable males and females (NCT02939703). In a metabolic ward where the environment was strictly controlled, we measured energy intake, energy expenditure, and energy output (fecal and urinary). The primary endpoint was the within-participant difference in host met

SUBMITTER: Corbin KD 

PROVIDER: S-EPMC10232526 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature