Volume atrophy in medial temporal cortex and verbal memory scores in American Indians: Data from the Strong Heart Study.

ABSTRACT:

Introduction

Distinguishing Alzheimer's disease (AD) patient subgroups may optimize positive clinical outcomes. Cortical atrophy is correlated with memory deficits, but these associations are understudied in American Indians.

Methods

We collected imaging and cognition data in the Strong Heart Study (SHS), a cohort of 11 tribes across three regions. We processed 1.5T MRI using FreeSurfer and iterative principal component analysis. Linear mixed models estimated volumetric associations with diabetes.

Results

Over mean 7 years follow-up (N = 818 age 65-89 years), overall volume loss was 0.5% per year. Significant losses associated with diabetes were especially strong in the right hemisphere. Annualized hippocampal, parahippocampal, entorhinal atrophy were worse for men, o

SUBMITTER: Suchy-Dicey A 

PROVIDER: S-EPMC10232670 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature