Prognostic value of human leukocyte antigen G expression in solid tumors: a systematic review and meta-analysis.

ABSTRACT:

Introduction

Identification of modulators of the immune response with inhibitory properties that could be susceptible for therapeutic intervention is a key goal in cancer research. An example is the human leukocyte antigen G (HLA-G), a nonclassical major histocompatibility complex (MHC) class I molecule, involved in cancer progression.

Methods

In this article we performed a systematic review and meta-analysis on the association between HLA-G expression and outcome in solid tumors. This study was performed in accordance with PRISMA guidelines and registered in PROSPERO.

Results

A total of 25 studies met the inclusion criteria. These studies comprised data from 4871 patients reporting overall survival (OS), and 961 patients, reporting disease free survival (DFS). HLA-G

SUBMITTER: Bartolome J 

PROVIDER: S-EPMC10232772 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature