Heart failure-related genes associated with oxidative stress and the immune landscape in lung cancer.

ABSTRACT:

Background

Lung cancer is a common comorbidity of heart failure (HF). The early identification of the risk factors for lung cancer in patients with HF is crucial to early diagnosis and prognosis. Furthermore, oxidative stress and immune responses are the two critical biological processes shared by HF and lung cancer. Therefore, our study aimed to select the core genes in HF and then investigate the potential mechanisms underlying HF and lung cancer, including oxidative stress and immune responses through the selected genes.

Methods

Differentially expressed genes (DEGs) were analyzed for HF using datasets extracted from the Gene Expression Omnibus database. Functional enrichment analysis was subsequently performed. Next, weighted gene co-expression network analysis was perfor

SUBMITTER: Duan R 

PROVIDER: S-EPMC10232804 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature