Ontology highlight
ABSTRACT:
SUBMITTER: Lie-Andersen O
PROVIDER: S-EPMC10232890 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Lie-Andersen Olivia O Hübbe Mie Linder ML Subramaniam Krishanthi K Steen-Jensen Daniel D Bergmann Ann Christina AC Justesen Daniel D Holmström Morten Orebo MO Turtle Lance L Justesen Sune S Lança Telma T Hansen Morten M
Frontiers in immunology 20230518
Induction of a lasting protective immune response is dependent on presentation of epitopes to patrolling T cells through the HLA complex. While peptide:HLA (pHLA) complex affinity alone is widely exploited for epitope selection, we demonstrate that including the pHLA complex stability as a selection parameter can significantly reduce the high false discovery rate observed with predicted affinity. In this study, pHLA complex stability was measured on three common class I alleles and 1286 overlapp ...[more]