Association of LIPC polymorphisms with stroke risk in the Chinese population.

ABSTRACT:

Background

Stroke is a common cerebrovascular disease. The purpose of this study was to explore the association between LIPC single nucleotide polymorphisms (SNPs) and the risk of stroke in the Chinese population.

Methods

This study recruited 710 stroke patients and 701 healthy controls. The four SNPs (rs690, rs6083, rs3829461, and rs6074) in LIPC were genotyped by the Agena MassARRAY. The correlation between LIPC polymorphisms and stroke risk was measured by odds ratio (OR) and 95% confidence interval (CI). In addition, multifactor dimensionality reduction (MDR) analysis was used to evaluate the impact of SNP-SNP interaction on stroke risk.

Results

Overall analysis showed that rs690 was associated with an increased risk of stroke (T vs. G: OR = 1

SUBMITTER: Pan J 

PROVIDER: S-EPMC10232962 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature