Radiation-induced circulating microRNAs linked to echocardiography parameters after radiotherapy.

ABSTRACT:

Introduction

Patients treated with radiotherapy to the chest region are at risk of cardiac sequelae, however, identification of those with greatest risk of complications remains difficult. Here, we sought to determine whether short-term changes in circulating miRNA expression are related to measures of cardiac dysfunction in follow-up.

Materials and methods

Two parallel patient cohorts were enrolled and followed up for 3 years after completion of RT to treat left-sided breast cancer. In the primary group (N=28) we used a a panel of 752 miRNAs to identify miRNAs associated with radiation and cardiac indices at follow up. In the second, independent cohort (N=56) we validated those candidate miRNAs with a targeted qPCR panel. In both cohorts. serum samples were collected before

SUBMITTER: Chalubinska-Fendler J 

PROVIDER: S-EPMC10232985 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature