Effect of guanylin peptides on pancreas steatosis and function in experimental diet-induced obesity and after bariatric surgery.

ABSTRACT:

Introduction

Obesity contributes to ectopic fat deposition in non-adipose organs, including the pancreas. Pancreas steatosis associates with inflammation and β-cell dysfunction, contributing to the onset of insulin resistance and type 2 diabetes. An improvement of pancreatic steatosis and indices of insulin resistance is observed following bariatric surgery, but the underlying mechanisms remain unknown. We sought to analyze whether guanylin (GUCA2A) and uroguanylin (GUCA2B), two gut hormones involved in the regulation of satiety, food preference and adiposity, are involved in the amelioration of pancreas fat accumulation after bariatric surgery.

Methods

Pancreas steatosis, inflammation, islet number and area were measured in male Wistar rats with diet-induced obesity (n=125)

SUBMITTER: Otero A 

PROVIDER: S-EPMC10233012 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature