Retinal ganglion cells undergo cell type-specific functional changes in a computational model of cone-mediated retinal degeneration.

ABSTRACT:

Introduction

Understanding the retina in health and disease is a key issue for neuroscience and neuroengineering applications such as retinal prostheses. During degeneration, the retinal network undergoes complex and multi-stage neuroanatomical alterations, which drastically impact the retinal ganglion cell (RGC) response and are of clinical importance. Here we present a biophysically detailed in silico model of the cone pathway in the retina that simulates the network-level response to both light and electrical stimulation.

Methods

The model included 11, 138 cells belonging to nine different cell types (cone photoreceptors, horizontal cells, ON/OFF bipolar cells, ON/OFF amacrine cells, and ON/OFF ganglion cells) confined to a 300 × 300 × 210μm patch of the parafoveal

SUBMITTER: Xu A 

PROVIDER: S-EPMC10233015 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature