Causal relationship in gut microbiota and upper urinary urolithiasis using Mendelian randomization.

ABSTRACT:

Background

Several reports in recent years have found an association between gut microbiota and upper urinary urolithiasis. However, the causal relationship between them remains to be clarified.

Methods

Genetic variation is used as a tool in Mendelian randomization for inference of whether exposure factors have a causal effect on disease outcomes. We selected summary statistics from a large genome-wide association study of the gut microbiome published by the MiBioGen consortium with a sample size of 18,340 as an exposure factor and upper urinary urolithiasis data from FinnGen GWAS with 4,969 calculi cases and 213,445 controls as a disease outcome. Then, a two-sample Mendelian randomization analysis was performed by applying inverse variance-weighted, MR-Egger, maximum likeli

SUBMITTER: Zhang R 

PROVIDER: S-EPMC10233049 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature