Skin permeation and penetration of mometasone furoate in the presence of emollients: An ex vivo evaluation of clinical application protocols.

ABSTRACT:

Background

Topical corticosteroids (TCS) and emollients are developed independently by the pharmaceutical industry but are often used together in practice. There is potential for the TCS and emollient formulations to interact on the skin surface affecting TCS absorption into the skin. Clinical guidelines acknowledge this issue but lack an evidence base and differ in their recommendations. There is a current clinical need to establish whether the application protocol employed for TCS and emollient products can impact delivery of TCS to the skin.

Objectives

To investigate whether the sequence of application of a TCS and emollient and the time between their application can affect TCS skin absorption.

Methods

The delivery of mometasone furoate (MF) to ex vivo human skin w

SUBMITTER: Beebeejaun MT 

PROVIDER: S-EPMC10233081 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature