Metronidazole for the treatment of cutaneous vulval Crohn disease: A systematic review.

ABSTRACT:

Background

Cutaneous vulval Crohn disease (VCD) is an under-recognised extra-intestinal manifestation of Crohn disease (CD) which is challenging to identify and treat. It causes significant oedema, painful deep fissures, and has potential to cause permanent disfiguring changes to vulval anatomy. There is no agreement on the best management for VCD.

Objectives

This systematic review evaluates the use of metronidazole for the treatment of VCD in women and children.

Methods

We conducted a systematic review (PROSPERO CRD42021285033) of the use of metronidazole in clinically or histologically diagnosed non-contiguous VCD in patients of all ages and ethnicities. We recorded clinical improvement, reduction in flares, relapse and adverse events using a standardised form.

R

SUBMITTER: Simon N 

PROVIDER: S-EPMC10233082 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature