Increased selenium and decreased iron levels in relation to risk of coronary artery disease in patients with diabetes.

ABSTRACT:

Background

Observational studies have reported inconsistent associations between micronutrient levels and the risk of coronary artery disease (CAD) in diabetic patients. We aim to explore the causal association between genetically predicted concentrations of micronutrients (phosphorus, magnesium, selenium, iron, zinc, and copper) and CAD in patients with diabetes.

Methods

Single nucleotide polymorphisms (SNPs) connected to serum micronutrient levels were extracted from the corresponding published genome-wide association studies (GWASs). Summary-level statistics for CAD in diabetic patients were obtained from a GWAS of 15,666 patients with diabetes. The primary analysis was carried out with the inverse variance weighted approach, and sensitivity analyses using other statistic

SUBMITTER: Tian M 

PROVIDER: S-EPMC10233138 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature