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Activation of brain arousal networks coincident with eye blinks during resting state.


ABSTRACT: Eye-blinking has been implicated in arousal and attention. Here we test the hypothesis that blinking-moments represent arousal surges associated with activation of the ascending arousal network (AAN) and its thalamic projections. For this purpose, we explored the temporal relationship between eye-blinks and fMRI BOLD activity in AAN and thalamic nuclei, as well as whole brain cluster corrected activations during eyes-open, resting-state fMRI scanning. We show that BOLD activations in the AAN nuclei peaked prior to the eye blinks and in thalamic nuclei peaked prior to and during the blink, consistent with the role of eye blinking in arousal surges. Additionally, we showed visual cortex peak activation prior to the eye blinks, providing further evidence of the visual cortex's role in arousal, and document cerebellar peak activation post eye blinks, which might reflect downstream engagement from arousal surges.

SUBMITTER: Demiral SB 

PROVIDER: S-EPMC10233245 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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Activation of brain arousal networks coincident with eye blinks during resting state.

Demiral Şükrü Barış ŞB   Kure Liu Christopher C   Benveniste Helene H   Tomasi Dardo D   Volkow Nora D ND  

Cerebral cortex (New York, N.Y. : 1991) 20230501 11


Eye-blinking has been implicated in arousal and attention. Here we test the hypothesis that blinking-moments represent arousal surges associated with activation of the ascending arousal network (AAN) and its thalamic projections. For this purpose, we explored the temporal relationship between eye-blinks and fMRI BOLD activity in AAN and thalamic nuclei, as well as whole brain cluster corrected activations during eyes-open, resting-state fMRI scanning. We show that BOLD activations in the AAN nuc  ...[more]

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