Liver transplantation in glycogen storage disease type Ib: The role of SGLT2 inhibitors.

ABSTRACT: We report on liver transplantation in two patients with GSD Ib on treatment with empagliflozin. The use of this SGLT2 inhibitor resulted in a marked decrease of 1,5-anhydroglucitol which has an important role in the development of neutropenia in this condition. As intended, this caused a significant rise of neutrophil numbers. Liver transplantation alone did not produce the desired effect and our observation argues for continuing SGLT2 inhibitor treatment after transplantation.

SUBMITTER: Murko S 

PROVIDER: S-EPMC10233270 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature