Progression of cerebral white matter hyperintensities is related to leucocyte gene expression.

ABSTRACT: Cerebral white matter hyperintensities are an important contributor to ageing brain pathology. Progression in white matter hyperintensity volume is associated with cognitive decline and gait impairment. Understanding the factors associated with white matter hyperintensity progression provides insight into pathogenesis and may identify novel treatment targets to improve cognitive health. We postulated that the immune system interaction with cerebral vessels and tissue may be associated with disease progression, and thus evaluated the relationship of blood leucocyte gene expression to progression of cerebral white matter hyperintensities. A brain MRI was obtained at baseline in 166 patients assessed for a cognitive complaint, and then repeated at regular intervals over a median of 5.9 years

SUBMITTER: Jickling GC 

PROVIDER: S-EPMC10233292 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature