Sex-specific effects of microglial activation on Alzheimer's disease proteinopathy in older adults.

ABSTRACT: Females show a disproportionate burden of Alzheimer's disease pathology and higher Alzheimer's disease dementia prevalences compared to males, yet the mechanisms driving these vulnerabilities are unknown. There is sexual dimorphism in immunological functioning, and neuroimmune processes are implicated in Alzheimer's disease genesis. Using neuropathology indicators from human brain tissue, we examined the mediational role of microglial activation on the relationship between amyloid and tau and how it differs by sex. 187 decedents (64% female; 89 mean age at death; 62% non-demented) from the Rush Memory and Aging Project completed neuropathological evaluations with brain tissue quantified for microglial activation, amyloid-β and tau. Proportion of morphologically activated microglia was dete

SUBMITTER: Casaletto KB 

PROVIDER: S-EPMC10233295 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature