Astrocyte immunometabolic regulation of the tumour microenvironment drives glioblastoma pathogenicity.

ABSTRACT: Malignant brain tumours are the cause of a disproportionate level of morbidity and mortality among cancer patients, an unfortunate statistic that has remained constant for decades. Despite considerable advances in the molecular characterization of these tumours, targeting the cancer cells has yet to produce significant advances in treatment. An alternative strategy is to target cells in the glioblastoma microenvironment, such as tumour-associated astrocytes. Astrocytes control multiple processes in health and disease, ranging from maintaining the brain's metabolic homeostasis, to modulating neuroinflammation. However, their role in glioblastoma pathogenicity is not well understood. Here we report that depletion of reactive astrocytes regresses glioblastoma and prolongs mouse survival. Anal

SUBMITTER: Perelroizen R 

PROVIDER: S-EPMC10233310 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature