Somatic Mosaic Chromosomal Alterations and Death of Cardiovascular Disease Causes among Cancer Survivors.

ABSTRACT:

Background

Cancer survivors are at an increased risk of cardiovascular disease (CVD) compared with the general population. We sought to evaluate the impact of mosaic chromosomal alterations (mCA) on death of CVD causes, coronary artery disease (CAD) causes, and of any cause in patients with a cancer diagnosis.

Methods

The study was a prospective cohort analysis of 48,919 UK Biobank participants with a cancer diagnosis. mCAs were characterized using DNA genotyping array intensity data and long-range chromosomal phase inference. Multivariable Cox regression models were used to ascertain the associations of mCAs. Exploratory endpoints included various incident cardiovascular phenotypes.

Results

Overall, 10,070 individuals (20.6%) carried ≥ 1 mCA clone. In adjusted analys

SUBMITTER: Sun M 

PROVIDER: S-EPMC10233351 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature