Progression of follicular lymphoma and related entities: Report from the 2021 SH/EAHP Workshop.

ABSTRACT:

Objectives

The 2021 Society for Hematopathology and European Association for Haematopathology Workshop addressed the molecular and cytogenetic underpinnings of transformation and transdifferentiation in lymphoid neoplasms.

Methods

Session 4, "Transformations of Follicular Lymphoma," and session 5, "Transformations of Other B-Cell Lymphomas," included 45 cases. Gene alteration analysis and expression profiling were performed on cases with submitted formalin-fixed, paraffin embedded tissue.

Results

The findings from session 4 suggest that "diffuse large B-cell lymphoma/high-grade B-cell lymphoma with rearrangements of MYC and BCL2" is a distinct category arising from the constraints of a preexisting BCL2 translocation. TdT expression in aggressive B-cell lymphomas is as

SUBMITTER: Duffield AS 

PROVIDER: S-EPMC10233403 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature