Enduring and Sex-specific Changes in Hippocampal Gene Expression after a Subchronic Immune Challenge.

ABSTRACT: Major illnesses, including heart attack and sepsis, can cause cognitive impairments, depression, and progressive memory decline that persist long after recovery from the original illness. In rodent models of sepsis or subchronic immune challenge, memory deficits also persist for weeks or months, even in the absence of ongoing neuroimmune activation. This raises the question of what mechanisms in the brain mediate such persistent changes in neural function. Here, we used RNA-sequencing as a large-scale, unbiased approach to identify changes in hippocampal gene expression long after a subchronic immune challenge previously established to cause persistent memory impairments in both males and females. We observed enduring dysregulation of gene expression three months after the end of a subchro

SUBMITTER: Tchessalova D 

PROVIDER: S-EPMC10233449 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature