Neuroinflammation After COVID-19 With Persistent Depressive and Cognitive Symptoms.

ABSTRACT:

Importance

Persistent depressive symptoms, often accompanied by cognitive symptoms, commonly occur after COVID-19 illness (hereinafter termed COVID-DC, DC for depressive and/or cognitive symptoms). In patients with COVID-DC, gliosis, an inflammatory change, was suspected, but measurements of gliosis had not been studied in the brain for this condition.

Objective

To determine whether translocator protein total distribution volume (TSPO VT), a marker of gliosis that is quantifiable with positron emission tomography (PET), is elevated in the dorsal putamen, ventral striatum, prefrontal cortex, anterior cingulate cortex, and hippocampus of persons with COVID-DC.

Design, setting, and participants

This case-control study conducted at a tertiary care psychiatric hospital in

SUBMITTER: Braga J 

PROVIDER: S-EPMC10233457 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature