Plasticity of Dental Cell Types in Development, Regeneration, and Evolution.

ABSTRACT: Recent years have improved our understanding of the plasticity of cell types behind inducing, building, and maintaining different types of teeth. The latest efforts were aided by progress in single-cell transcriptomics, which helped to define not only cell states with mathematical precision but also transitions between them. This includes new aspects of dental epithelial and mesenchymal stem cell niches and beyond. These recent efforts revealed continuous and fluid trajectories connecting cell states during dental development and exposed the natural plasticity of tooth-building progenitors. Such "developmental" plasticity seems to be employed for organizing stem cell niches in adult continuously growing teeth. Furthermore, transitions between mature cell types elicited by trauma might repr

SUBMITTER: Krivanek J 

PROVIDER: S-EPMC10233505 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature