Genetic and Nongenetic Determinants of Variable Warfarin Dose Requirements: A Report from North India.

ABSTRACT:

Introduction

Warfarin is widely used and will continue to be prescribed especially in developing countries due to its low cost. Given the huge patient load requiring anticoagulation, there is a need to develop strategies to optimize warfarin therapy for ensuring safe and effective anticoagulation. In the present work, we aimed at elucidating the association of genetic and nongenetic variables with warfarin dose requirement in patients attending the cardiovascular clinic in a tertiary care center of North India.

Methods

This was a prospective study conducted over 1 year. Patient demographic and clinical details were captured in customized case record forms. Genotyping was done using the polymerase chain reaction-restriction fragment length polymorphism method. Pharmacogenetic

SUBMITTER: Kaur N 

PROVIDER: S-EPMC10233675 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature