Myo-Inositol Potentiates the Inhibitory Effect of Metformin on Prolactin Levels.

ABSTRACT:

Introduction

Metformin was found to reduce elevated levels of anterior pituitary hormones. Its thyrotropin-lowering effect was more pronounced in individuals receiving myo-inositol. The aim of the present study was to investigate whether the concomitant supplementation of myo-inositol determines the impact of metformin on prolactin levels.

Methods

The study population consisted of two groups of women with mild-to-moderate hyperprolactinemia. Group 1 included 24 individuals receiving myo-inositol preparations (2 g daily for at least 6 months), while 24 inositol-naïve women belonged to group 2. Both groups were matched for age, insulin sensitivity, and prolactin concentration. For the following 6 months, all women were treated with metformin (1.7 daily). Plasma glucose levels,

SUBMITTER: Krysiak R 

PROVIDER: S-EPMC10233678 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature