Immunotherapy for Pediatric Brain and Spine Tumors: Current State and Future Directions.

ABSTRACT:

Background

Brain tumors are the most common solid tumors and the leading cause of cancer-related deaths in children. Incidence in the USA has been on the rise for the last 2 decades. While therapeutic advances in diagnosis and treatment have improved survival and quality of life in many children, prognosis remains poor and current treatments have significant long-term sequelae.

Summary

There is a substantial need for the development of new therapeutic approaches, and since the introduction of immunotherapy by immune checkpoint inhibitors, there has been an exponential increase in clinical trials to adopt these and other immunotherapy approaches in children with brain tumors. In this review, we summarize the current immunotherapy landscape for various pediatric brain tumor ty

SUBMITTER: Estevez-Ordonez D 

PROVIDER: S-EPMC10233708 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature