Amphid sensory neurons of Caenorhabditis elegans orchestrate its survival from infection with broad classes of pathogens.

ABSTRACT: The survival of a host during infection relies on its ability to rapidly sense the invading pathogen and mount an appropriate response. The bacterivorous nematode Caenorhabditis elegans lacks most of the traditional pattern recognition mechanisms. In this study, we hypothesized that the 12 pairs of amphid sensory neurons in the heads of worms provide sensing capability and thus affect survival during infection. We tested animals lacking amphid neurons to three major classes of pathogens, namely-a Gram-negative bacterium Pseudomonas aeruginosa, a Gram-positive bacterium Enterococcus faecalis, and a pathogenic yeast Cryptococcus neoformans By using individual neuronal ablation lines or mutants lacking specific neurons, we demonstrate that some neurons broadly supp

SUBMITTER: Venkatesh SR 

PROVIDER: S-EPMC10233725 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature