Frequency of quorum-sensing mutations in Pseudomonas aeruginosa strains isolated from different environments.

ABSTRACT: Pseudomonas aeruginosa uses quorum sensing (QS) to coordinate the expression of multiple genes necessary for establishing and maintaining infection. It has previously been shown that lasR QS mutations frequently arise in cystic fibrosis (CF) lung infections, however, there has been far less emphasis on determining whether other QS system mutations arise during infection or in other environments. To test this, we utilized 852 publicly available sequenced P. aeruginosa genomes from the Pseudomonas International Consortium Database (IPCD) to study P. aeruginosa QS mutational signatures. To study isolates by source, we focused on a subset of 654 isolates collected from CF, wounds, and non-infection environmental isolates, where we could clearly identify their

SUBMITTER: O'Connor K 

PROVIDER: S-EPMC10233726 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature