Sterically Stabilized Diblock Copolymer Nanoparticles Enable Efficient Preparation of Non-Aqueous Pickering Nanoemulsions.

ABSTRACT: We report the first example of a non-aqueous Pickering nanoemulsion, which comprises glycerol droplets dispersed in mineral oil. The droplet phase is stabilized by hydrophobic sterically stabilized poly(lauryl methacrylate)-poly(benzyl methacrylate) nanoparticles which are prepared directly in mineral oil using polymerization-induced self-assembly. First, a glycerol-in-mineral oil Pickering macroemulsion with a mean droplet diameter of 2.1 ± 0.9 μm is prepared via high-shear homogenization using excess nanoparticles as an emulsifier. Then, this precursor macroemulsion is subjected to high-pressure microfluidization (a single pass at an applied pressure of 20,000 psi) to produce glycerol droplets of approximately 200-250 nm diameter. Transmission electron microscopy studies indicate preserv

SUBMITTER: Hunter SJ 

PROVIDER: S-EPMC10233796 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature