Application of Nanomagnetic Metal-Organic Frameworks in the Green Synthesis of Nicotinonitriles via Cooperative Vinylogous Anomeric-Based Oxidation.

ABSTRACT: In the current study, we synthesized a new nanomagnetic metal-organic framework Fe₃O₄@MIL-53(Al)-N(CH₂PO₃)₂ and characterized it using various techniques. This nanomagnetic metal-organic framework was used for the synthesis of a wide range of nicotinonitrile derivatives as suitable drug candidates by a four-component reaction of 3-oxo-3-phenylpropanenitrile or 3-(4-chlorophenyl)-3-oxopropanenitrile, ammonium acetate (NH₄OAc), acetophenone derivatives, and various aldehydes including those bearing electron-donating, electron-withdrawing, and halogen groups, which afforded desired products (27 samples) via a cooperative vinylogous anomeric-based oxidation (CVABO) mechanism under solvent-free conditions in excellent yields (68-

SUBMITTER: Danishyar B 

PROVIDER: S-EPMC10233831 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature