Dataset Information

GPR43 stimulation on TCRαβ⁺ intraepithelial colonic lymphocytes inhibits the recruitment of encephalitogenic T-cells into the central nervous system and attenuates the development of autoimmunity.

ABSTRACT:

Introduction

Gut microbiota plays a critical role in the regulation of immune homeostasis. Accordingly, several autoimmune disorders have been associated with dysbiosis in the gut microbiota. Notably, the dysbiosis associated with central nervous system (CNS) autoimmunity involves a substantial reduction of bacteria belonging to Clostridia clusters IV and XIVa, which constitute major producers of short-chain fatty acids (SCFAs). Here we addressed the role of the surface receptor-mediated effects of SCFAs on mucosal T-cells in the development of CNS autoimmunity.

Methods

To induce CNS autoimmunity, we used the mouse model of experimental autoimmune encephalomyelitis (EAE) induced by immunization with the myelin oligodendrocyte glycoprotein (MOG)-derived peptide (MOG_35-55

SUBMITTER: Prado C

PROVIDER: S-EPMC10233874 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Dataset Information

GPR43 stimulation on TCRαβ⁺ intraepithelial colonic lymphocytes inhibits the recruitment of encephalitogenic T-cells into the central nervous system and attenuates the development of autoimmunity.

Introduction

Methods

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

GPR43 stimulation on TCRαβ+ intraepithelial colonic lymphocytes inhibits the recruitment of encephalitogenic T-cells into the central nervous system and attenuates the development of autoimmunity.

Introduction

Methods

OmicsDI is part of the ELIXIR infrastructure

Tweets

GPR43 stimulation on TCRαβ⁺ intraepithelial colonic lymphocytes inhibits the recruitment of encephalitogenic T-cells into the central nervous system and attenuates the development of autoimmunity.