Chemical-genomic profiling identifies genes that protect yeast from aluminium, gallium, and indium toxicity.

ABSTRACT: Aluminium, gallium, and indium are group 13 metals with similar chemical and physical properties. While aluminium is one of the most abundant elements in the Earth's crust, gallium and indium are present only in trace amounts. However, the increased use of the latter metals in novel technologies may result in increased human and environmental exposure. There is mounting evidence that these metals are toxic, but the underlying mechanisms remain poorly understood. Likewise, little is known about how cells protect themselves from these metals. Aluminium, gallium, and indium are relatively insoluble at neutral pH, and here we show that they precipitate in yeast culture medium at acidic pH as metal-phosphate species. Despite this, the dissolved metal concentrations are sufficient to induce toxi

SUBMITTER: Schulze Y 

PROVIDER: S-EPMC10233895 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature