Genetic determinants of Biofilm formation of Helicobacter pylori using whole-genome sequencing.

ABSTRACT:

Background

Infection with Helicobacter pylori as the cause of gastric cancer is a global public health concern. In addition to protecting germs from antibiotics, biofilms reduce the efficacy of H. pylori eradication therapy. The nucleotide polymorphisms (SNPs) related with the biofilm forming phenotype of Helicobacter pylori were studied.

Results

Fifty-six H. pylori isolate from Bangladeshi patients were included in this cross-sectional study. Crystal violet assay was used to quantify biofilm amount, and the strains were classified into high- and low-biofilm formers As a result, strains were classified as 19.6% high- and 81.4% low-biofilm formers. These phenotypes were not related to specific clades in the phylogenetic analysis. The accessories genes associated with biofilm

SUBMITTER: Fauzia KA 

PROVIDER: S-EPMC10234030 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature