Sexual dimorphism in mitochondrial dysfunction and diabetes mellitus: evidence from a population-based cohort study.

ABSTRACT:

Background

Pathophysiological mechanisms underlying sex-based differences in diabetes remain poorly understood. Mitochondrial metabolite methylmalonic acid (MMA) accumulation reflects mitochondrial dysfunction which is involved in sex-specific pathophysiological responses biologically. We aimed to investigate the sex-specific associations between mortality risk and MMA in adults with the presence or absence of type 2 diabetes.

Methods

This cohort study included 24,164 adults (12,123 females and 12,041 males) from the NHANES study during 1999-2014. Both sexes were separately categorized as those with no diabetes, prediabetes, undiagnosed diabetes, and diagnosed diabetes. Circulating MMA level was measured at baseline by mass-spectrometric detection. Mortality status was ascer

SUBMITTER: Wang S 

PROVIDER: S-EPMC10234037 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature