Addition of cariogenic pathogens to complex oral microflora drives significant changes in biofilm compositions and functionalities.

ABSTRACT:

Background

Dental caries is a microbe and sugar-mediated biofilm-dependent oral disease. Of particular significance, a virulent type of dental caries, known as severe early childhood caries (S-ECC), is characterized by the synergistic polymicrobial interaction between the cariogenic bacterium, Streptococcus mutans, and an opportunistic fungal pathogen, Candida albicans. Although cross-sectional studies reveal their important roles in caries development, these exhibit limitations in determining the significance of these microbial interactions in the pathogenesis of the disease. Thus, it remains unclear the mechanism(s) through which the cross-kingdom interaction modulates the composition of the plaque microbiome. Here, we employed a novel ex vivo saliva-derived microcosm biofilm mod

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10234067 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature