The effect of anti-inflammatory treatment on depressive symptoms in spondyloarthritis: does the type of drug matter?

ABSTRACT:

Objective

To investigate the effect of pharmacological treatment of SpA on depressive symptoms and explore whether this effect differs between drug classes.

Methods

Data from the observational Assessment of SpondyloArthritis international Society Health Index Validation Study were used. Patients were assessed at baseline and after initiation of NSAIDs/conventional synthetic DMARDs (csDMARDs)/TNF inhibitors (TNFis). Depressive symptoms were assessed with the Hospital Anxiety and Depression Scale depression subscale [HADS-D; 0-21 (best-worst)]. Covariables included demographics and disease characteristics, including disease activity [Ankylosing Spondylitis Disease Activity Score (ASDAS)/BASDAI]. The change in HADS-D from baseline was compared between treatments (NSAIDs/csDMARD

SUBMITTER: Webers C 

PROVIDER: S-EPMC10234195 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature