A comprehensive review of 30 years of pediatric clinical trial radiotherapy dose constraints.

ABSTRACT:

Background

Radiation therapy normal tissue dose constraints are critical when treating pediatric patients. However, there is limited evidence supporting proposed constraints, which has led to variations in constraints over the years. In this study, we identify these variations in dose constraints within pediatric trials both in the United States and in Europe used in the past 30 years.

Procedure

All pediatric trials from the Children's Oncology Group website were queried from inception until January 2022 and a sampling of European studies was included. Dose constraints were identified and built into an organ-based interactive web application with filters to display data by organs at risk (OAR), protocol, start date, dose, volume, and fractionation scheme. Dose constraints we

SUBMITTER: Vassantachart A 

PROVIDER: S-EPMC10234212 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature